A Causative Role for Amylin in Diabetic Peripheral Neuropathy

Status: Recruiting
Location: See all (2) locations...
Study Type: Observational
SUMMARY

Three pieces of information lead to the basis for this study: 1. Individuals with Type-2 diabetes commonly develop peripheral neuropathy. 2. Increased production of the hormone amylin occurs in individuals who have Type-2 diabetes. 3. Aggregations of amylin was found in the peripheral vasculature of rats that overexpressed human amylin. The purpose of this study is to determine whether a correlation exists between the amount of amylin present in the upper extremities of human subjects with Type-2 diabetes and the extent to which symptoms of peripheral neuropathy are expressed in those subjects. The investigators will be testing this by initially collecting blood and skin biopsy samples from subjects, followed by measuring patient sensation and pain responses to heat, cold, and pressure in the upper extremities.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Subject has been diagnosed with Type-2 Diabetes.

• Subject shows mild-to-severe peripheral neuropathy, as determined by Nerve Conduction Velocity (NCV) tests.

Locations
United States
Kentucky
UK Robert Straus Behavioral Science Laboratory
ACTIVE_NOT_RECRUITING
Lexington
University of Kentucky - Kentucky Neuroscience Institute
RECRUITING
Lexington
Contact Information
Primary
Rani Priyanka Vasireddy, MBBS, MHA
rvasireddy@uky.edu
859-218-5076
Backup
John T Slevin, M.D., M.B.A.
jslevin@email.uky.edu
8593236702
Time Frame
Start Date: 2018-02-05
Estimated Completion Date: 2029-01
Participants
Target number of participants: 40
Sponsors
Leads: Zabeen Mahuwala, MD

This content was sourced from clinicaltrials.gov